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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2164 | Wiskostatin | Others | |
Wiskostatin is a selective inhibitor of N-WASP, a ubiquitously expressed member of the Wiskott-Aldrich Syndrome protein (WASp) family that regulates actin polymerization. | |||
T23372 | SMIFH2 | Others | |
SMIFH2 is formin homology 2 (FH2) domains inhibitor. | |||
T22260 | Aminopurvalanol A | CDK | |
Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 n... | |||
T5007 | Benproperine phosphate | Blascorid,Pirexyl phosphate | Others , Microtubule Associated |
Benproperine phosphate (Pirexyl phosphate) is a cough suppressant. | |||
T13864 | Resolvin D1 | RvD1 | Apoptosis |
Resolvin D1 (RvD1) is an endogenous pro-inflammatory mediator that blocks pro-inflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α-mediated inflammation in macrophages, and enhances macroph... | |||
T1820 | CK-636 | CK-0944636,CK 636 | Microtubule Associated |
CK-636 (CK-0944636), an Arp2/3 complex inhibitor, can inhibit actin polymerization induced by the human (IC50: 4 μM), fission yeast (IC50: 24 μM) and bovine (IC50: 32 μM) Arp2/3 complex, respectively. | |||
T5S1981 | Alpha-Cyperone | (+)-α-Cyperone,α-Cyperone | Others , Endogenous Metabolite |
1. alpha-Cyperone (α-Cyperone) is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium. 2. alpha-Cyperone significantly inhibited PGE2 production by suppressing the LPS-induced... | |||
T15721 | Latrunculin A | LAT-A | Others |
Latrunculin A is a toxin isolated from the red sea sponge Latrunculia magnifica. Latrunculin A binds to actin monomers and it also inhibits polymerization of actin (Kds: 0.1, 0.4, 4.7 μM, and 0.19 μM for ATP-actin, ADP-P... | |||
T35609 | 19-O-Acetylchaetoglobosin A | ||
19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated fromC. globosumthat has actin polymerization inhibitory and cytotoxic activities.1,2It inhibits actin polymerization in a cell-free assay when used a... | |||
TP1977 | 187-1, N-WASP inhibitor | ||
Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not di... | |||
T36358 | Diminutol | ||
Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis. At 50 μM, it directly affects tubulin polymerization ... | |||
T10928 | Cytochalasin A | HIV Protease | |
Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), inhibits actin polymerization and interferes with microtubu... | |||
T36402 | Kibdelone C | ||
Kibdelone C is a member of a family of natural heterocyclic polyketides first isolated from a soil actinomycete, Kibdelosporangium. Kibdelones have been described as having potent and selective cytotoxicity against a pan... | |||
T83715 | Histatin 3 TFA | Hst-3 | |
Histatin 3, a salivary antimicrobial peptide, exhibits activity against C. albicans with an LC50 of 9.2 µM. Additionally, at a concentration of 12 µM, it promotes actin polymerization in cell-free assays. | |||
T20636 | Latrunculin B | LAT-B,LATB,NSC 339663,NSC339663,NSC-339663,LAT B,INS115644 | Antifungal |
Latrunculin B, an alkaloid from the Red Sea sponge, is an actin polymerization inhibitor with antifungal and antiprotozoal activity.Latrunculin B modulates the electrophysiological characteristics of the pulmonary veins ... | |||
T73498 | EG-011 | ||
EG-011, a first-in-class and potent activator of Wiskott-Aldrich syndrome protein (WASP), effectively activates the auto-inhibited form of WASP, leading to strong actin polymerization. This compound demonstrates selectiv... | |||
T82934 | AuM1Phe | Topoisomerase | |
AuM1Phe, an N-heterocyclic carbene (NHC) metal complex, inhibits both human topoisomerase I activity and actin polymerization. It also impedes the proliferation of MDA-MB-231 breast cancer cells, exhibiting an IC50 value... | |||
T69269 | DMGF | ||
DMGF, also known as 7,7-dimethoxyagastisfavone, is a biflavonoid isolated from Taxus × media cv. Hicksii. DMGF induces apoptotic and autophagic cell death. DMGF could effectively attenuate the motility of B16F10 cells, a... | |||
T11712 | Jasplakinolide | Jaspamide,NSC-613009 | Microtubule Associated , Antifungal |
Jasplakinolide(Jaspamide), a naturally occurring cyclic peptide from marine sponges, is a potent inducer of actin polymerization.Jasplakinolide exhibits antifungal and antitumor activity and stabilizes pre-existing actin... | |||
T65390 | Fluvoxketone | ||
Fluvoxketone is trifluoromethyl-substituted aryl ketone compound useful as an intermediate in the synthesis of Fluvoxamine, which is a selective serotonin reuptake inhibitor. In the synthesis of Fluvoxamine, the ketone c... |